Each capsule contains: Paracetamol B.P 325 mg; Ibuprofen B.P 200 mg; Caffeine (Anhydrous) B.P 30 mg

IBUMED PLUS is combination of the above three ingredients: Ibuprofen is a non¬steroidal anti-inflammatory agent & possesses analgesic and anti-Inflammatory activities. Controlled studies have demonstrated that Ibuprofen is a more effective analgesic than propoxyphene for the relief of episiotomy pair, pain following dental extraction procedures and for the relief of the symptoms of primary dysmenorrhoea.

Ibuprofen is rapidly absorbed when administered orally. Peak serum Ibuprofen levels are generally attained within one or two hours after administration. There is no evidence of drug accumulation or enzyme induction.

Paracetamol is the main metabolite of Phenacetin, without the side effects of phenacetin. The efficiency of Paracetamol as an analgesic and antipyretic is equivalent to that of acetylsalicylic acid, but it has no ant-inflammatory properties. Paracetamol has no effect on the Prothrombin time and does not appear to produce significant changes in the gastric mucosa.

Paracetamol is rapidly and almost completely absorbed from the gastro-intestinal tract following oral administration. Peak plasma levels occur in about 30 minutes to 2 hours after administration.

Approximately 20% to 50% is bound to plasma proteins and is metabolised in the liver largely to Gluconamide and Sulphate Conjegates and eliminated in the urine. There is no synergic antipyretic or analgesic effect between Paracetamol and Ibuprofen. Caffeine stimulates the CNS.